Transmission consequences of coinfection: cytokines writ large?

نویسندگان

  • Andrea L Graham
  • Isabella M Cattadori
  • James O Lloyd-Smith
  • Matthew J Ferrari
  • Ottar N Bjørnstad
چکیده

Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour--focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.

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عنوان ژورنال:
  • Trends in parasitology

دوره 23 6  شماره 

صفحات  -

تاریخ انتشار 2007